Today one of the most important challenges for Intellectual and Developmental Disability (IDD) organizations is how to align support needs to personal outcomes, through the implementation of an effective and efficient Individualized Support Plan (ISP). The matrix system is based on the alignment approach. This system is divided in three phases: INPUT (assessment phase); THROUGHPUT (implementation process phase); OUTPUT (evaluation phase). The focus of this work is INPUT phase. This study focuses on the assessment to define best general life aims for persons with IDD. Input starts on assessing what is important to the person. An interview is conducted with the person about desires, expectations, hopes and interests. In cases where the self-report is impossible, other instruments, as direct observation, are necessary. The information is fully integrated by interviewing family members and other caregivers. The second step consists in assessing support needs, adaptive behavior, intelligence quotient, functioning, health and barriers and facilitators in the environment. The date collected is an incredible source of knowledge about the person with IDD, but the relevance of every piece information in Quality of Life domains have to be understood. The matrix system helps professionals to sort the information collected, create hierarchies of importance and identify meaningful goals for people with IDD. The purpose of this work is to create examples of INPUT, in persons with IDD in a residential service in Italy using the matrix system, and to define significant paths and best general life aims to improve Quality of Life.